While it is understood that a Bone Marrow Aspirate Concentrate Stem Cell intervention introduces a cartilage regeneration potential via Mesenchymal Stem Cells, continued research is expanding our knowledge as to what else is in the concentrate in addition to stem cells. For instance, many have heard the story of basketball legend Kobie Bryant’s trip to Germany several years ago and the success of the procedure called IRAP wherein Interleukin 1 Receptor Antagonist Protein was concentrated after a blood draw over a four day period and injected into his arthritic knee with great success allowing him to return to professional basketball. There followed many professional athletes and famous persons. Most recently, I read of Willie Nelson’s converting a failed rotator cuff repair into a functioning painless shoulder with IRAP. There have been marked improvements though in the non surgical approach to arthritis and soft tissue injury since the introduction of IRAP, we know it as Bone Marrow Aspirate Concentrate and Stem cells.

OA progression is due, at least in part, to the up-regulation of inflammatory mediators and proteases after injury.  Since elevated levels of catabolic enzymes in synovial fluid (SF) are associated with chondrocyte death and cartilage matrix degeneration within 1 week of injury, early intervention strategies should focus on modulating these cartilage-degrading enzymes within this time frame. Evidence suggests that the molecules and growth factors in the Bone Marrow Concentrate target these enzymes arresting adverse events and preserving joint health. That’s why in addition to pain relief and improved function, our informed consent speaks toward actually reversing the arthritic process.

Alpha’2Macroglobulin is a negative regulator of cartilage catabolic enzymes but that it is not present in vivo at sufficient levels to counteract the increased concentrations of catabolic factors that appear after injury. Therefore, the  intraarticular  injection of  alpha’2M via bone marrow concentrate in addition to the stem cells along with all the other growth factors  contained in bone marrow , when concentrated, is the only means of actually treating arthritis other than a joint replacement. All other medicinal and pharmacologic approaches are directed to the symptoms but not the disease.

Alpha2Macroglobulin is a powerful inhibitor of many cartilage catabolic factors and it can attenuate posttraumatic OsteoArthritic cartilage degeneration in the animal model… Alpha2-macroglobulin is a major protease inhibitor; the largest fraction is produced by the liver while the synovium produces smaller amounts.

In summary, up-regulation of cartilage catabolic cytokines and enzymes is thought to be a key mechanism of cartilage damage. Thus, inhibition of these molecules will likely slow or prevent the progression of disease while the stem cells regenerate the joint. If you want to learn more, call 847 390 7666.

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