I am an Orthopedic Surgeon; not an orthopedic physician or one of the many charlatans who hold themselves out as “specialists” in regenerative medicine. To be a Board Certified Orthopedic Surgeon and Fellow of the American Academy of Orthopedic Surgeons is an arduous undertaking requiring many years of education and surgical training as well as successful completion of many examinations. To upload a stem cell website and start offering regenerative care, all the charlatans have to do is attend a weekend course. Along the way, most of these rip-offs sell nutraceuticals either in their offices or online for financial reward without science to support the claims of benefit. There is an exception. This Blog will feature scientific evidence to support the value of Vitamin D supplementation in those with low levels.
Vitamin D status is associated with inflammatory biomarkers and clinical symptoms in patients with knee osteoarthritis
Published: April 29, 2022
Abstract
Background and aim
The association between vitamin D status and osteoarthritis (OA) and bone remodeling has been shown previously. The present study was conducted to determine the association between vitamin D status and inflammatory biomarkers and clinical symptoms in patients with knee OA.
Methods
This case-control study was performed on 124 subjects with mild to moderate knee OA and 65 healthy controls. Demographic data was collected from all participants at baseline. We used Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC Index) for evaluating the severity of clinical symptoms in these patients. Serum levels of vitamin D, as well as markers of inflammation including interleukin 1-β (IL-1β), interleukin 6 (IL-6), interleukin 10 (IL-10), tumor necrosis factor-alpha (TNF-α), high-sensitivity C-reactive protein (hs-CRP), and nuclear factor k-B (NF-κB), p65 were evaluated for each participant.
Results
The results of the present study showed that patients with knee OA had lower levels of vitamin D and higher levels of IL-1β, TNF-α, hs-CRP, and NF-кB p65 compared with healthy controls (P < 0.0001). The levels of IL-1β, TNF-α, and NF-кB p65 in knee OA patients with vitamin D insufficiency were significantly higher compared with the knee OA patients with sufficient vitamin D (P < 0.05). Based on the linear regression analysis, serum vitamin D levels were inversely correlated with IL-1β, TNF-α, hs-CRP, and NF-кB p65 levels (P < 0.0001). Patients with sufficient vitamin D levels had lower total and physical function WOMAC scores compared with patients with vitamin D insufficiency (P = 0.011 and P = 0.010, respectively).
Conclusion
The results suggest a strong link between vitamin D deficiency and increased inflammatory biomarkers as well as increased severity of clinical symptoms in knee OA patients.
I am off to Poway, California, the home of Personalized Stem Cells on June 14 and 15 to have my own adipose tissue harvested and stored in anticipation of FDA approval of the next clinical trial using my own stem cells for arthritic joints. If you want to learn more, read my website at www.sheinkopmd.com or upload the www.persoanlizedstemcell.com website.
To make an office appointment call (847)390-7666. In addition to the upcoming clinical trial, we offer a range of biologics for arthritis including bone marrow concentrate containing your stem cells as well as biologics based on your growth factors and anti-inflammatory proteins circulating in your blood.