Dec 29, 2020
“Hello, I thought you would like to know that my stem cell in my left knee has worked. I didn’t expect it to take so long but I have had little to no pain for the past two months. Thank you all again for your care and please advise your patients to be patient! If not for Covid, I would have had knee replacement several months ago. Only good thing about Covid!”
I received this e-mail message of gratitude this morning and I began to think what this patient’s recovery might have been following a Total Knee Replacement (TKR). In the latter scenario, maximum medical improvement is not realized on the average for over six months or longer. Following a Stem Cell procedure, Maximum Medical Improvement may take six months or longer. In the population of patients who undergo a TKR, 40% are left with an incomplete recovery; that is, some pain and a significant permanent loss of motion. In those who opt for the Stem Cell intervention to relieve symptoms of arthritis and improve functional capacity, our data suggest 10% of patients don’t experience satisfaction. Following a failed Total Knee Replacement, outcome, the choices are to accept the permanent alteration of life style or undergo yet a second major surgical procedure; namely, a revision (ouch). Following a Stem cell procedure that doesn’t provide the sought-after outcome, we still offer a needle and not a knife to improve the end results.
Looking back at 2020 and looking forward to 2021, based on observations following our regenerative medicine interventions, I will adjust my post intervention management with a more concentrated Growth Factor/ PRP booster. Our evidence-based results over the past several months using Growth Factors in higher concentrations have been most rewarding. As many readers of this Blog are aware, I am working closely with Personalized Stem Cells, Inc. and the FDA to help launch the next Adipose based Stem Cell Clinical Trial. It is our hope that the Trial will be approved by the end of Q1 or the start of Q2. In the interim, if you are experiencing pain and functional limitation from knee arthritis, consider a Growth Factor /PRP concentrate intervention. While there is an out-of-pocket fee for the treatment to keep you going, ultimately, for those who meet the inclusion criteria for the PSC Clinical Trial, there will be a facility fee but no out of pocket expense for the entire Adipose Based Stem Cell undertaking.
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Tags: arthritis, arthritis treatment, regenerative medicine, stem cell, stem cell therapy
Oct 6, 2016
“Growth factor, any of a group of proteins that stimulate the growth of specific tissues. Growth factors play an important role I promoting cellular differentiation and cell division,” and they occur in bone marrow as well as your circulating blood.
“When investigators began studying the effects of biological substances on cells and tissues in culture, they discovered a group of peptide-hormone-like substances that were distinct from any previously known hormones. Because these substances were active in stimulating the growth of cells and tissues, they were called growth factors. Some growth factors are similar to hormones in that they can be secreted into the blood stream, which carries them to their target tissues. However, whereas the production of hormones is limited to glandular tissue, growth factors can be produced by many different types of tissue” and cells for that matter.
When a patient presents for a Bone Marrow Concentrate procedure for an arthritic joint in order to prevent, perhaps even avoid a joint replacement, the understanding to date is that it will be Mesenchymal Stem Cell that will serve as the key factor in reducing pain, increasing motion, improving function and influencing the progression of arthritis. The latter is only partially true but fails to address the role Growth Factors play in Cellular Orthopedics (Regenerative Medicine). When your orthopedic surgeon tells you that Stem Cells won’t work for your arthritis, schedule your joint replacement, that physician doesn’t understand that Stem cells are only part of what Bone Marrow concentrate provides us in assisting the patient with an arthritic joint, return to an active life style without surgery.
We now have several proprietary means of not only concentrating adult Mesenchymal Stem Cells but Growth Factors as well when addressing your arthritic joint with Bone Marrow Concentrate. While stem cells may be impacted by age, Growth Factors do not seem to be adversely impacted accounting for several recent successes with patients in their 90s. Since we have been concentrating stem cells with growth factors and combining the approach to the joint with subchondroplasty, we continue to document improving outcomes
Tags: arthritic pain, arthritis, arthritis treatment, Bone Marrow Concentrate, Concentrated Stem Cell Plasma, Growth Factors, Hip Replacement, joint replacement, Mesenchymal Stem Cell, Orthopedic Surgeon, Osteoarthritis, regenerative medicine, Regenerative Pain Center, stem cell treatment
Aug 11, 2014
Last Thursday, I presented my Data on our minimum 12 month Outcomes regarding Marrow Aspirate Concentrate derived Stem Cells for Osteoarthritis of the knee to the Regenexx 3rd Annual Conference. It was held at the Scientific and Research Institute in Thornton, Colorado. The baseline number included 118 patients. While I presented the customary orthopedic objective data on the patient cohort such as point scores, Range of motion, patient satisfaction, psychological profiles and pain scores, I introduced two new Scoring parameters: 1) Activity Scores and 2) Comparison to Knee Replacement Outcomes.
Activity Scores are increasingly recognized as an objective outcome measurement documenting results without superimposed psychological disability, sociological factors, and serves as a quantitative measure of how much rather than how well. We measured impact sports breaking them down into very active categories, active, moderate and mild categories. In each category, the patients who had undergone stem cell intervention scored very well in either returning to a prior level of activity recently abandoned or actually advancing to a higher category of activity. As an example, I saw a patient last week six weeks past stem cell intervention for osteoarthritis of the knee. He had presented for treatment when his ability to walk was less than a city block. He marched in six weeks post treatment without a smile indicating that he was dissatisfied, as he still needed to use a handrail for stairs. When I asked him how he got to the office for the six-week follow-up, he responded that he had walked from home. I then inquired how far? His response ” 3 and 1/2 miles”.
In comparing knee replacement outcomes to stem cell interventions, the mean functional score for patients who had received Total Knee Prosthesis at a minimum of one year was 67. In comparison, the functional score for BMAC Stem Cell interventions was 90.5. While it may be that the stem cell population was not exactly comparable to those who had received a Total Knee Replacement, you decide, knee replacement or try stem cells first.
Tags: arthritis, arthritis treatment, athletes, Bone Marrow Concentrate, Clinical Trial. Mitchell B. Sheinkop, Hip Replacement, Interventional Orthopedics, Mature Athlete, Orthopedic Surgeon, Osteoarthritis, Regenexx-SD, stem cells