Special Announcement - Now Enrolling for FDA Approved Stem Cell Study
Dr. Mitchell Sheinkop has completed training and is credentialed for the first of its kind FDA approved stem cell clinical trial for knee arthritis. Our clinic is now enrolling patients in this trial. Contact us at 312-475-1893 for details. Click here to learn more.
On Stem Cells, Bone Marrow Concentrate and Non-unions of Bones

On Stem Cells, Bone Marrow Concentrate and Non-unions of Bones

With all of our attention directed to arthritis, patients need to be reminded of the continued successes we are experiencing when using Bone Marrow Concentrate in fractures that fail to heal. When a fracture fails to heal in the expected average time, that is a Delayed Union. When it looses the ability to heal all together, that’s a Non-Union. The reasons that a fracture might fail to heal are beyond the scope of this Blog but non-union is not a rare complication. Areas of predilection toward difficulty in healing have to do with blood supply. The upper end of the femur (hip), navicular bone at the wrist, upper end of the humerus (shoulder), and clavicle as well as the tibia are areas of predilection. Historically, the only remedy has been a major operative procedure and even at that, there is a high failure rate with multiple complications including infection. It has been said that the only thing worse than an infected non-union is cancer. Let me share with you the story of two recent patients for whom I successfully intervened with Bone Marrow Concentrate when prior attempts at achieving fracture healing, one through surgery had failed.

VDVR is a 46-year-old woman who ten years ago sustained multiple fractures to her spine and lower extremities while serving in Iraq. She had undergone numerous surgical procedures, all successful except the inability to cause healing of fractures to her left calcaneus and talus. She had been left with Oxycontin addiction and crutch dependency. After several further orthopedic consultations she had a choice of amputation or more major surgical repair attempts with only 50% chance of success. Twelve weeks ago, I performed a Bone Marrow Concentrate/ Stem Cell intervention to her left calcaneus and talus. Last week she called and indicated she no longer required narcotics and could walk without crutches. The X-ray I received a day or two after the call was indicative of fracture healing.

JM is a 76-year old man with an established non-union of the left clavicle, of several years duration. He was experiencing arthritic changes in his left shoulder and asked me to try and achieve healing of the clavicle, even after several years while I was injecting Bone Marrow Concentrate into his arthritic left shoulder.  About 16 weeks ago, I completed a stem cell intervention to his left shoulder and into the area of non-union of the outer one-third of the left clavicle. When I saw him in follow-up last week, the collarbone was completely healed. He had been afraid to undergo a surgical repair because of the high incidence of infection, failure and neurovascular injury associated with surgery of non-union at the clavicle.

These are but two illustrations of what is happening in the new world of Cellular Orthopedics. The initiative is gaining traction in the orthopedic world as I more and more success stories are realized

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On Stem Cells, Bone Marrow Concentrate and Non-unions of Bones

I have arthritis. Give me Bone Marrow Concentrate or Give me a Joint Replacement

Orthopedic Care of the Mature Athlete

The established practice leading to a diagnosis of knee osteoarthritis is based on evidence of joint pain and/or reduced space between articulating bone surfaces on X-Ray. That loss of space in the radiograph is attributed to thinning of opposing articular cartilages in your knee. New evidence however, indicates that multiple tissues composing the knee joint appear to be compromised by the disease, including the subchondral bone (bone below and supporting cartilage), articluar cartilage, the meniscus, the anterior cruciate ligament, the synovium, and the synovial fluid. A change in any of these tissues can influence load across the joint, with corresponding adaptations in the other tissues and ultimately, the cartilages. (Taken from “On the Horizon from the ORS). I `believe it important to provide continual explanation about how Regenerative Medicine works, it isn’t only fish oil. We are continuing to learn more and more about the world of Regenerative Medicine and the reason for the effectiveness of bone marrow concentrate and why BMC is proving so affective in dealing with the musculoskeletal system. It isn’t only attributable to the Adult Mesenchymal Stem Cell.

I have a fracture and it won’t heal

Let me introduce you to another component within Bone Marrow Aspirate, the Endothelial Progenitor Cell. EPCs can be defined as bone marrow-derived precursor cells with the ability to differentiate into endothelial cells and to participate in the formation of new blood vessels. Recent research indicates that Mesenchymal Stem Cells “talk” to Endothelial Progenitor Cells. It seems that in fracture repair, the synergistic effect of EPCs and MSCs is crucial for complete bone regeneration. Positive effects of Endothelial Progenitor therapy have been demonstrated in ligament tissue regeneration, as well. Regenexx has demonstrated several cases of effecting healing of a torn Anterior Cruciate Ligament using Bone Marrow Concentrate. It may well be that the Endothelial Progenitor Cells are responsible for new blood vessels and a resultant favorable environment. Delayed healing of fractures (delayed union) and a failure of healing (non-union) can be devastating to an individual. If you are that patient, ask your orthopedic surgeon about A Novel Cell-based therapy in Orthopedic Surgery: Endothelial Progenitor Cells. The bone marrow is aspirated and concentrated and then injected into the fracture site using a minimal invasive needle technique. If you are directed to surgery instead, give me a call.

Did you see that NFL Monday night Football Game? Stem Cells won that game! More about this next week.

 

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