A Short Course on Regenerative Medicine: A Needle, not a knife
Wharton’s Jelly
The amount of growth factors, cytokines, hyaluronic acid, cellular components and extracellular vesicles are higher in Wharton’s Jelly compared to other biologics. These components aid in strength, flexibility, cushioning, covering, compressibility and response to friction in the body. It also plays a vital role in reducing inflammation. Derived for umbilical cord tissue, the safety and efficacy in osteoarthritis is under clinical trial and not yet FDA approved for unapproved application.
Hyaluronic Acid
Naturally present in the body, hyaluronic acid acts as a cushion and lubricant for the joints and other tissues. Hyaluronic acid can be used for various joint disorders and aging among other conditions. It may promote healthier, more supple skin, speed up wound healing and preserve bone strength.
Proteins and Amino Acids
Required for the structure, function and regulation of the body’s tissues and organs, proteins help repair tissues and allow metabolic reactions to occur. Some proteins are chemical messengers between cells, tissues and organs while others provide structure and support. The building blocks of proteins, amino acids are vital for protein synthesis, tissue repair and nutrient absorption.
Collagens
Collagens form a scaffold to provide strength and structure throughout the body delivering a platform for new tissue growth. As long as Collagen application is without cellular content, the acellular collagen may be used under the auspices of an IRB trial ongoing in my practice.
Cytokines
These molecules serve as messengers between cells, mediating and regulating immunity, inflammation and hematopoiesis. They stimulate the production of blood cells and provide growth and differentiation factions that function in development, tissue maintenance and repair.
Chemokines
A form of cytokine that stimulates movement and plays a crucial role in immunological reactions.
Growth Factors
Regulate cell division and cell survival to stimulate the growth of a specific tissue. Via a blood draw (vena-puncture) in my office followed by centrifugation and filtration, I am able to inject the anti-inflammatory proteins into your joint
Exosomes
Scientists believe that these membrane-bound particles produced by cells and platelets contain DNA, messenger RNA, microRNA, et., and are the means by which Stem Cells and Platelets influence coagulation, Regeneration, and waste management within the body. On May 31,2021, the FDA prohibited the use of donor exosomes; however, when derived from your platelets, they are readily accessible and approved for treating arthritis via a recently approved technique.
Mesenchymal Stem Cells
Derived from your bone marrow, MSCs continue to be the most researched means of relieving the pain and inflammation in an osteoarthritic joint. Relatively abundant in your bone marrow, by aspiration from your pelvis followed by concentration, when the proper indications for application are met, BMC is a proven means of aiding in postponing, perhaps avoiding a Total Joint Replacement
Stromal Vascular Fraction
The term applies to mesenchymal stem cells harvested from adipose tissue (fat) obtained by a mini-liposuction. While not yet FDA approved, I was part of an FDA monitored clinical trial, recently completed for osteoarthritis at the knee and we are waiting for FDA approval of a second phase larger and longer clinical trial. Visit www.personalizedstemcells.com to learn more.
To schedule a consultation for care of your arthritic joint, call 312-475-1893.
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