Is it the stem cells or the growth factors?

The New York Times: 2019/05/13 “Stem cell Treatments Flourish with Little Evidence That They Work”

Several years ago, I asked a question of a cellular biologist as to how is Bone Marrow Concentrate effective if the number of adult mesenchymal stem cells diminish as we age? His response: “Bone Marrow contains lots of things including stem cells and proteins called cytokines or growth factors. It may be that the growth factors are most important in joint restoration and blocking pain.”

Let’s take for example, inflammatory arthritis such as Rheumatoid and Psoriatic arthritis. The common denominator is a pro-inflammatory cytokine called Tissue Necrosis Factor found in the body’s immune system.  The growth factor, TNF-alpha blocker is now used to control the inflammation and alter the body’s immune response to the proinflammatory protein. As a result of TNF-alpha blockers, Phil Mickelson is a very competitive golf professional, (You have seen him as a spokes person for Psoriatic Arthritis treatment with Humira). Since the introduction of TNF alpha blockers in Scandinavia five years ago, there has been a 40% reduction in Total Knee Replacements for inflammatory arthritis. When Kobe Bryant traveled to Dusseldorf, Germany almost nine years ago, he received treatment for a very arthritic knee with Interleukin -1 Receptor Antagonist Protein, along with other blockers. Shortly thereafter, he returned to play another five years in the NBA. The IRAP that Bryant received was and is an anti-inflammatory, a growth factor blocker, a cytokine.

As I agree in part with the  criticism in the New York Times concerning Stem Cells, those who read this Blog will recall that I don’t “sell” stem cells. Bone Marrow is used in part because of the fact that it contains stem cells; but more importantly as we age, Bone Marrow contains Growth Factors, the anti-inflammatory protein Cytokines that restore a joint by minimizing pain and improving function. Over the last eight years, we have accumulated the evidence that Bone Marrow Concentrate works for arthritis via stem cells, growth factors, or all of the above. Recently we have taken a major step forward by filtering high concentrations of Growth Factors from the Platelet Poor Plasma, previously discarded, that remained after we centrifuge the bone marrow and add the filtrate to that which is injected into the painful joint. Stem Cells maybe, highly concentrated Growth Factors that act to block pain and improve function, for certain.

You may learn more by visiting my web site at www.sheinkopmd.com  or call for a consultation (847)390-7666

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What does Dr. Mitchell Sheinkop have in common with Kobe Bryant?

What does Dr. Mitchell Sheinkop have in common with Kobe Bryant?

For one, to the best of my knowledge, he doesn’t ski but I did earn a letter as a member of the Roosevelt High, basketball team. No, the common ground is the fact that we both have undergone a similar intervention for osteoarthritis of the knee. Six years or so before Bryant’s retirement, he traveled to Dusseldorf, Germany to undergo an orthobiologic intervention for an arthritic knee that was threatening to prematurely end his playing career. That orthobiologic intervention was unavailable at the time in the United States; but professional athletes were traveling to Dusseldorf to help prolong their careers. I closely followed the outcomes and was amazed to see Kobe Bryant’s return to professional basketball following his procedure for five more years, given he had stage four Osteoarthritis of his knee. His knee X-Ray was available on the internet. At the same time, I postponed my surgical procedures knowing that both of my knees and both of my hips were problematic, waiting for access to a treatment similar to that which the professional athletes were having in Europe. Last September, as an invited speaker at the Russian Orthopedic Society annual meeting, I was able to gain access to the treatment regimen very much available by now in Western Europe and Great Britain. My hope was to partake in a family ski vacation from February 17 to 24. On December 27, I underwent biologic intervention into both of my knees; and on January 11, both of my hips.

On Saturday, I returned from a ski week in Vail, including my wife, three children, one daughter-in-law and five grandchildren. Two other spouses don’t ski. I skied six consecutive days with my wife, children and at times, grandchildren. It was an opportunity for returning to the thrilling days of yesteryear as far as skiing was concerned, made possible by Orthobiologics.  Imagine, three months ago I was experiencing painful limitations in both hips and in both knees; now I am planning a return four-day skiing visit at the end of March to catch the spring powder. I don’t know if I can help you ski; but I can help you overcome limitations imposed by arthritic joints.

Citing Oliver Wendel Holmes; “We do not quit playing because we grow old; we grow old because we quit playing”.

To learn more visit:      www.ilcellulartherapy.com  or call for an appointment   312 475 1893

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Cellular Orthopedics, looking back and looking forward

Cellular Orthopedics, looking back and looking forward

Or as Dan Brown’s Origin explores, “Where did we come from, where are we going?”

It seems customary to make predictions at this time of year; but I want to begin by looking back four decades. It is more than reminiscence. Until managed health care was introduced into the marketplace undermining the doctor-patient relationship, a patient would make health care decisions for the most part based on the trust and confidence established with the family physician. Then came what was promoted as New Horizons of Health Care; mainly insurance based decision making. Hailed as the means of controlling spiraling health care costs, the doctor-patient relationship was no longer primary. The model changed health care decision making from a physician to a non-professional employee sitting in front of a computer and determining your care based on a cost containment paradigm. The next step in devolution was the appearance of Web MD and the like were in everyone thought they could become a physician and expert in some aspect of health care by simply clicking on a mouse. No need now for a physician or expert any longer; why bother with someone educated in medical school and struggling through a lengthy residency and then fellowship? Then appeared the next step in Gulliver’s Travels, further devolution or the opportunity for camp followers and charlatans to exploit the belief that marketing would outweigh evidence and science in a patient’s decision-making process.

Unfortunately, the FDA is only now beginning to police these amniotic fluid stem cell purveyors offering false hope. We have experienced a study process of lowering standards, further eroding norms, and peddling fiction.  Where are we going; where should you turn for orthopedic care?

Today, I am undergoing a cellular orthopedic intervention on my knees so as to assure my best possible performance when I fly fish, ski, cycle, and maintain my fitness profile in 2018. The process is an autologous therapy (from me to me), that I have wanted to bring to the United States since Kobe Bryant and many more travelled to Dusseldorf, Germany, to have completed over seven years ago. The promise is to do more than treat my knee pain; rather I hope to slow the progression of my Osteoarthritis with this cell-concentration system.  

The poet Robert Browning wrote a poem, Rabbi Ben Ezra, often cited as we age and I will quote the opening stanza here:

“Grow old along with me! The best is yet to be”

You may read the entirety at the Poetry Foundation website. You may watch my webinar on my web site at www.Ilcellulartherapy.com. Call to schedule appointment (847) 390-7666.

Read this Blog to monitor my response to treatment

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